… screening of new therapeutic agents, we have developed a two-step protocol for testing
suramin derivatives … as suramin to induce the differentiation of the human colic adenocarcinema …

… Here, we provide an overview of the many different … , more specific, and less toxic molecules
can be identified for the … least) two pathways for receptor-mediated endocytosis of suramin in …

… to this list inhibition by suramin of at least two targets within the … administration of suramin
results in multiple toxicities and the … of human colon cancer and lung cancer cells both in vitro …

… of suramin and serum albumin in human colon cancer cells (HT-29-D4) upon suramin
treatment. … were performed on HT-29-D4 cells grown in serum free medium containing both [ 3 H]…

… of suramin has been also reported on the human stomach … to suramin (2 h) could augment
CEA secretion from this cell. … Cell toxicity was observed with concentrations above 4 μg/ml of …

… Furthermore, the development of less toxic analogs of suramin that … : Double screening of
suramin derivatives on human colon cancer cells and on neural cells provides new therapeutic …

… In the last two decades, appreciable progress has been … , chemotherapeutic agents have
significant toxicity and badly … In a cohort study with 15,052 colorectal cancer patients, that …

… adult brain and testis, and in human colon carcinoma cell lines [58]. Recently, suramin (1) has
… an anabolic effect in bone, suggesting this protein as a potentially useful therapeutic agent …

… target for the delivery of therapeutic agents. A synthetic nano-… with suramin compared to the
control without suramin (12% … and receptor activity has been observed in colon cancer [53], …

… , colorectal cancer, colon cancer, pancreatic cancer and high… that suramin induces activation
of Src and AKT, two important … suramin has significant toxicity when it is used as a cytotoxic …